Replication data for Colorectal cancer initiation by benzo[a]pyrene and N-nitroso compounds in A/J Min/+ mice

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Johanson, Silje Modahl, 2025, "Replication data for Colorectal cancer initiation by benzo[a]pyrene and N-nitroso compounds in A/J Min/+ mice", https://doi.org/10.18710/PIJGRT, DataverseNO, V1

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Description	The dataset contains the complete raw data for the results presented in the manuscript Colorectal cancer initiation by benzo[a]pyrene and N-nitroso compounds in A/J Min/+ mice. The raw data were obtained from A/J Min/+ mice dietary exposed to individual or combined benzo[a]pyrene and n-nitroso compounds (NOCs) at low or high doses. The main objective of the study was to characterize the carcinogenic potential of single or combined exposure to BaP and NOCs in the A/J Min/+ mouse model for colorectal cancer. The data includes various weights and lengths measurement, scoring of lesions in the small and large intestine , histopathology of lesions larger than 0,1962mm2 in the colorectum, and targeted plasma metabolomics. The aim was achieved by macroscopic investigations of intestinal tissue and histopathological characterization using light microscopy, in addition to targeted metabolomics of blood plasma using the p400 Biocrates kit. (2024-09-16)
Subject	Medicine, Health and Life Sciences
Keyword	Benzo[a]pyrene, N-nitroso compounds, A/J Min/+ mouse, Colorectal cancer, Targeted metabolomics
Related Publication	Is Supplement To: Johanson, S. M., T. H. Kleiven, L. Ivanova, O. D. R. Huerta, C. P. Åkesson, A. A. Niklas, K. Granby, E. Ropstad, J. E. Paulsen, and M. H. B. Müller. 2025. Colorectal cancer initiation by benzo[a]pyrene and N-nitroso compounds in A/J Min/+ mice. Food and Chemical Toxicology:115902.doi: 10.1016/j.fct.2025.115902
License/Data Use Agreement	CC0 1.0

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	00_README.txt Plain Text - 35.1 KB Published Dec 17, 2025 1 Download MD5: e251a216f4313d5335c3026a6266fab5	Preview "00_README.txt" Access File File Access Public Download Options Plain Text Download Metadata Data File Citation Download EndNote XML Download RIS Download BibTeX
	01_Weights_and_lengths_raw_data.txt Plain Text - 10.9 KB Published Dec 17, 2025 0 Downloads MD5: e7ea7da016ecb2e5a3260f9a0cd1a4c1 Complete raw data of weights and lengths from A/J Min/+ mice.	Preview "01_Weights_and_lengths_raw_data.txt" Access File File Access Public Download Options Plain Text Download Metadata Data File Citation Download EndNote XML Download RIS Download BibTeX
	02_Intestinal_cancer_raw_data.txt Plain Text - 28.2 KB Published Dec 17, 2025 0 Downloads MD5: 64861da1342fb4a35a70c9c1fe55aa12 Compiled raw data from scoring of intestinal lesions in A/J Min/+ mice.	Preview "02_Intestinal_cancer_raw_data.txt" Access File File Access Public Download Options Plain Text Download Metadata Data File Citation Download EndNote XML Download RIS Download BibTeX
	03_targeted_metabolomics_concentration_data.txt Plain Text - 120.9 KB Published Dec 17, 2025 0 Downloads MD5: dd60701822ca79166ea43e628c0c19d2 Concentration data of metabolites from the targeted metabolomics analysis of blood plasma from A/J Min/+ mice.	Preview "03_targeted_metabolomics_concentration_data.txt" Access File File Access Public Download Options Plain Text Download Metadata Data File Citation Download EndNote XML Download RIS Download BibTeX

Citation Metadata

Persistent Identifier	doi:10.18710/PIJGRT
Publication Date	2025-12-17
Title	Replication data for Colorectal cancer initiation by benzo[a]pyrene and N-nitroso compounds in A/J Min/+ mice
Author	Norwegian University of Life Sciences (NMBU)0000-0001-8377-7824
Point of Contact	Use email button above to contact. Johanson, Silje Modahl (Norwegian University of Life Sciences (NMBU))
Description	The dataset contains the complete raw data for the results presented in the manuscript Colorectal cancer initiation by benzo[a]pyrene and N-nitroso compounds in A/J Min/+ mice. The raw data were obtained from A/J Min/+ mice dietary exposed to individual or combined benzo[a]pyrene and n-nitroso compounds (NOCs) at low or high doses. The main objective of the study was to characterize the carcinogenic potential of single or combined exposure to BaP and NOCs in the A/J Min/+ mouse model for colorectal cancer. The data includes various weights and lengths measurement, scoring of lesions in the small and large intestine , histopathology of lesions larger than 0,1962mm2 in the colorectum, and targeted plasma metabolomics. The aim was achieved by macroscopic investigations of intestinal tissue and histopathological characterization using light microscopy, in addition to targeted metabolomics of blood plasma using the p400 Biocrates kit. (2024-09-16)
Subject	Medicine, Health and Life Sciences
Keyword	Benzo[a]pyrene N-nitroso compounds A/J Min/+ mouse Colorectal cancer (CRC) Targeted metabolomics
Related Publication	Is Supplement To: Johanson, S. M., T. H. Kleiven, L. Ivanova, O. D. R. Huerta, C. P. Åkesson, A. A. Niklas, K. Granby, E. Ropstad, J. E. Paulsen, and M. H. B. Müller. 2025. Colorectal cancer initiation by benzo[a]pyrene and N-nitroso compounds in A/J Min/+ mice. Food and Chemical Toxicology:115902. doi 10.1016/j.fct.2025.115902 https://www.sciencedirect.com/science/article/pii/S0278691525006702
Language	English
Producer	Norwegian University of Life Sciences (NMBU) (NMBU) https://www.nmbu.no/en
Production Date	2021-02-09
Production Location	Section for Experimental Biomedicine, Norwegian University of Life Science, Oslo, Norway
Contributor	Project Leader: Müller, Mette Helen Bjørge Project Leader: Paulsen, Jan Erik Data Collector: Kleiven, Thea Heimstad Data Collector: Ivanova, Lada Data Curator: Huerta, Oscar Daniel Rangel Data Curator: Ropstad, Erik Data Collector: Åkersson, Caroline Piercey Data Collector: Granby, Kit Data Collector: Niklas, Agnieszka A
Funding Information	The Research Council of Norway: 280667
Distributor	Norwegian University of Life Sciences (NMBU) (NMBU) https://dataverse.no/dataverse/nmbu
Distribution Date	2024-09-16
Depositor	Johanson, Silje Modahl
Deposit Date	2024-09-11
Date of Collection	Start Date: 2021-02-09; End Date: 2021-04-22
Data Type	Experimental data
Software	Microsoft Excel, Version: 365 AbsoluteIDQ® p400 HR kit (Biocrates Life Science AG), Version: Oxygen-DB110-3023 Xcalibur (Thermo Fisher Scientific), Version: 4.2.28.14

Life Sciences Metadata

Factor Type	Biomarkers; Disease State; Sex; Tissue Type; Treatment Compound; Treatment Type
Other Factor Type	Plasma metabolites
Organism	Mus musculus
Measurement Type	copy number variation profiling; histology; metabolite profiling; Other
Other Measurement Type	Count, Area, Weight, Length, Incidence
Technology Type	mass spectrometry; Other
Other Technology Type	Microscopy, Histopathology
Technology Platform	Other
Other Technology Platform	Vanquish Horizon ultrahigh-performance liquid chromatography (UHPLC) coupled to a Q-Exactive Fourier-transform high-resolution mass spectrometer (Thermo Fisher Scientific) and equipped with a heated electrospray interface (HESI-II)

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